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What Is Stereology?Stereology is simply the study of estimating geometric quantities—obtaining information from flat, two-dimensional images.In 1961, the journal Science carried the following announcement: "An International Society of Stereology (the science of three-dimensional interpretation of flat images) has been formed for the exchange of ideas concerning applicable research methods in microanatomy, cytology, ultrastructure studies, metallurgy, geology, astronomy, and cosmology. Inquiries are invited concerning membership, or the activities of the society." There are many examples today of estimating geometric quantities that are 2-dimensional. The more challenging concepts deal with the estimation of 3-dimensional quantities based on the observation of 2-dimensional images. Today, the field of stereology has evolved to include the study quantification in 3 dimensions. In fact, today the most common estimates are quantities in 3-dimensional material. Examples of this are the number of brain cells within a brain region, the length of capillaries, the volume of a tumor, as well as the percentage of quartz in granite. In recent years, advent of design-based stereology has improved the accuracy and reliability of quantification in biological research. The application of design-based stereological methods to the analysis of the central nervous system, as well as other organs, has contributed considerably to our understanding of the functional and pathological morphology of the body. More Information about StereologyStereology.info provides the most comprehensive information about stereology on the web. Designed to introduce both basic and advanced concepts in the field of stereology, the emphasis is on the use of stereology in biological research, though anyone interested in learning the basic concepts of stereology will find something of interest. |
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Stereology System
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Stereology Contract ServicesA trusted component of stereological analyses for pharmaceutical, biomedical, and neuroscience research, MBF Labs services are ideal for anyone looking for expert stereological analysis but lacking in-house instrumentation or expertise. MBF Labs scientists and technicians collect the data, interpret the results, and prepare a final report. Whether it is brain, lung, or other biological tissue, MBF Labs will get accurate results needed for research. Stereology CoursesNeuroStereology Workshop - An Introduction to Stereology for NeuroscientistsOrganized by Dr. Mark West March 19-24, 2011 Woodshole, Massachusetts USA Short Description A two day course to be held immediately prior to the meeting of the Society for Neuroscience in San Diego at the Horton Grand Hotel. The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary. The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction. Organizer: Mark West Professor of Medical Neurobiology, author of the most cited scientific papers on the application of modern stereological methods to the nervous system. Practical Workshop in Confocal Microscopy and Stereology Organized by Dr. Daniel Peterson Short Description - Graduate students who need to use modern microscopy or stereology in their projects - Postdoctoral fellows who would benefit from a comprehensive introduction to microscopy and stereology - Young investigators who need to incorporate these analytical approaches into their labs - Investigators new to histological analysis who need a rapid and complete introduction to these techniques Lecturer Space is limited to the first 30 registrants for each session. Two graduate student scholarships are available. For more information, to download the course program, or to register, please visit: www.neurorenew.com NeuroStereology Workshop – An Introduction to Stereology for Neuroscientists Short Description A two day course to be held immediately prior to the meeting of the Society for Neuroscience in San Diego at the Horton Grand Hotel. The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary. Organizer: Mark WestProfessor of Medical Neurobiology, author of the most cited scientific papers on the application of modern stereological methods to the nervous system. Sixth Course “Morphometry and Stereology in Neurosciences” To be held in the colloquium room, MF-H-161, of the Dept. Anatomy & Neurosciences/Pathology, VU University Medical Center (VUmc), Van der Boechorststraat 7, Amsterdam Short Description
Practical Training Course in Confocal Microscopy and Stereology Short Description Who Should Attend Lecturer Space is limited to the first 20 registrants for each session. Two graduate student scholarships are available. For more information, to download the course program, or to register, please visit: www.neurorenew.com Stereology Course at the University of Vermont The Microscopy Imaging Center at the University of Vermont is offering a hands-on course in practical stereology July 21-23, 2010, in Burlington, VT taught by internationally respected experts. This 3 day practical course is designed for advanced students, post-doctoral fellows, technicians, and principal investigators seeking to understand the principles of stereology as applied to microscopy and other imaging modalities. Faculty:
NeuroStereology Workshop Short Description Unlike previously available methods, these newer methods produce accurate and robust estimates of total quantities, such as number, length, area and volume. Because of the enhanced power of the data obtained with these methods, they have recently made important contributions to our understanding of the changes in the structure of the brain related to aging and disease and are rapidly becoming the standards required by journals and granting agencies. The mathematical basis and practical application of these methods will be presented through a series of lectures, practical exercises, demonstrations, and critical evaluations of individual projects. Particular emphasis will be placed on design based, stereological methods that have particular relevance to the study of the nervous system, such as estimates of: 1) the numbers of neurons and synapses, the length of axons and capillaries, and the volumes of brain regions, layers; 2) the volumes and spatial arrangement of individual cells and pathological entities. Who Should Attend The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.Course Director Instructors NeuroStereology Workshop Short Description Unlike previously available methods, these newer methods produce accurate and robust estimates of total quantities, such as number, length, area and volume. Because of the enhanced power of the data obtained with these methods, they have recently made important contributions to our understanding of the changes in the structure of the brain related to aging and disease and are rapidly becoming the standards required by journals and granting agencies. The mathematical basis and practical application of these methods will be presented through a series of lectures, practical exercises, demonstrations, and critical evaluations of individual projects. Particular emphasis will be placed on design based, stereological methods that have particular relevance to the study of the nervous system, such as estimates of: 1) the numbers of neurons and synapses, the length of axons and capillaries, and the volumes of brain regions, layers; 2) the volumes and spatial arrangement of individual cells and pathological entities. Who Should Attend University of Aarhus Denmark International Symposium: Recent Advances in Imaging for Neuroscience 2nd Annual Course on Design Based Stereology The purpose of this workshop is to strengthen the theoretical background and practical skills of the academic community interested in modern techniques of design based stereology currently used in the field of neuroscience. The workshop is designed for graduate students, post-docs, and investigators interested in introducing advanced microscopy and stereology techniques in their research studies and labs. Dr. José Maldonado, staff scientist at MBF Bioscience, will lead the course.
Short Description A limited number of participants will be selected for the course and workshop. Applications: Fellowships: The course is admission free. Fellowships are available to cover the full or partial cost of travel, housing, and meals. Students should apply for fellowships by sending a letter to Marcela Díaz. Preliminary list of issues to be covered:
For a Preliminary Program and additional information (in Spanish): www.iibce.edu.uy Invited Instructors: Stereology Seminar – Applying the Principles of Unbiased Stereology to Scientific Studies Fundamentals in Neuroscience: Morphological and Behavioral Approaches Short Description The course has a comprehensive one-day theoretical content supported by a strong practical component (4 days). At the end of the course attendants should be able to correlate morphological aspects with behavioral performance and choose and manipulate the appropriate laboratory tools. Program
Workshops include:
Course Directors Dr. José Miguel Pêgo is an auxiliary professor at the School of Health Sciences, University of Minho enrolled in the teaching of pharmacology. His research activities have been centered in the behavioral and morphological characterization of animal models of anxiety. Presently he is mainly focused on the molecular mechanisms underlying neuroplasticity in stress models of anxiety. He is experienced in rodent behavior analysis, stereology and 3D reconstruction of neurons. Space is limited to the first 30 registrants. For more information or to register, please visit the conference website. Note: MBF has a policy of not promoting courses that are taught by commercially affiliated instructors. There are other stereology courses that are offered by organizations that use instructors with direct commercial interests in the products that are demonstrated during these courses. If you have a doubt, ask the instructor directly if they have a commercial affiliation with the products demonstrated at their course. Contact MBF if you have any questions about courses not listed here or about our policy. Copyright MBF Bioscience 2011 |
